Swelling During Late Pregnancy
As pregnancy progresses, fluid may accumulate in tissues,
usually in the feet, ankles, and legs, causing them to swell and appear puffy.
This condition is called edema. Occasionally, the face and hands also swell.
Some fluid accumulation during pregnancy is normal, particularly during the 3rd
trimester. It is called physiologic edema.
Fluid accumulates during pregnancy because the adrenal
glands produce more of the hormones that make the body retain fluids
(aldosterone and cortisol). Fluid also accumulates because the enlarging uterus
interferes with blood flow from the legs to the heart. As a result, fluid backs
up in the veins of the legs and seeps out into the surrounding tissues.
Causes
Common causes
Usually during pregnancy, swelling is
Physiologic edema
Less common causes
Less commonly, swelling during pregnancy results from a
disorder (see table Some Causes and Features of Swelling During Late
Pregnancy). However, such disorders are often serious. They include the
following;
Deep vein thrombosis
Preeclampsia
Peripartum cardiomyopathy (heart failure that develops late
in pregnancy or after delivery)
Cellulitis
In deep vein thrombosis, blood clots form in veins located
deep within part of the body, often in the legs. Pregnancy increases the risk
of this disorder in several ways. During pregnancy, the body produces more of
the proteins that help blood clot (clotting factors), probably intended to
prevent too much bleeding during childbirth. Also, changes during pregnancy
cause blood to back up in veins, making clots more likely to form. If the
pregnant woman is less mobile, blood is even more likely to back up in leg
veins and clot. The clots may interfere with blood flow. If a blood clot breaks
loose, it can travel through the bloodstream to the lungs, blocking blood flow
there. This blockage (called pulmonary embolism) is life threatening.
In preeclampsia, blood pressure and protein levels in urine
increase during pregnancy. Fluids may accumulate, causing swelling in the face,
hands, or feet and weight gain. If severe, preeclampsia can damage organs, such
as the brain, kidneys, lungs, or liver, and cause problems in the baby.
Peripartum cardiomyopathy causes shortness of breath and
fatigue as well as swelling.
In cellulitis, bacteria infect the skin and tissues under
the skin, sometimes causing swelling with redness and tenderness. Cellulitis
most commonly affects the legs but may occur anywhere.
Risk factors
The risk of deep vein thrombosis and preeclampsia is
increased by various conditions (risk factors).
For deep vein thrombosis, risk factors include the
following:
A previous episode of deep vein thrombosis
- Inherited blood clotting disorders
- Injury to a leg vein that prevents blood from flowing normally
- A disorder that makes blood more likely to clot, such as cancer or kidney or heart problems
- Cigarette smoking
- Immobility, as may occur after an illness or surgery
- Obesity
For preeclampsia, risk factors include
- High blood pressure that was present before pregnancy
- Preeclampsia during a previous pregnancy or a family member who has had preeclampsia
- Age under 17 or over 35
- A first pregnancy
- A pregnancy with more than one fetus
- Diabetes
- Blood vessel (vascular) disorders
- A hydatidiform mole (abnormal growth of the placenta with or without a fetus due to an abnormally fertilized egg)
For peripartum cardiomyopathy, risk factors include the
following:
- Age 30 or older
- A previous diagnosis of cardiomyopathy or other heart problem
- African descent
- A pregnancy with more than one fetus
- Preeclampsia
- High blood pressure that was present before pregnancy
Doctors must rule out deep vein thrombosis, preeclampsia, a
heart disorder, cellulitis, and other possible causes before they can diagnose
physiologic edema.
Warning signs
In pregnant women with swollen legs, the following symptoms
are cause for concern:
- Blood pressure that is 140/90 mm Hg or higher
- Swelling in only one leg or calf, particularly if the area is warm, red, and/or tender or fever is present
- Swelling in the hands
- Swelling that suddenly increases
- Confusion, difficulty breathing, changes in vision, shaking (tremor), a seizure, sudden abdominal pain, or a sudden headache—symptoms that may be caused by preeclampsia
- Chest pain
When to see a doctor
Women should go to the hospital immediately if they have
Symptoms that suggest preeclampsia or a heart disorder
Women with other warning signs should see a doctor that day.
Women without warning signs should see a doctor, but a delay of several days is
usually not harmful.
What the doctor does
Doctors first ask questions about the swelling and other
symptoms and about the medical history. Doctors then do a physical examination.
What they find during the history and physical examination often suggests a
cause of the swelling and the tests that may need to be done (see table Some
Causes and Features of Swelling During Late Pregnancy).
Doctors ask the following:
When the swelling started
How long it has been present
Whether any activity (such as lying on the left side)
lessens or worsens it
Lying on the left side decreases physiologic edema.
Doctors also ask about conditions that increase the risk of
developing deep vein thrombosis, preeclampsia, and peripartum cardiomyopathy.
Women are asked about other symptoms, which may suggest a
cause. They are asked whether they have ever had deep vein thrombosis,
pulmonary embolism, preeclampsia, high blood pressure, or heart problems,
including cardiomyopathy.
During the physical examination, doctors look for evidence
of a serious cause. To check for symptoms of preeclampsia, doctors measure
blood pressure, listen to the heart and lungs, and may check the woman's
reflexes and look at the back of her eyes with an ophthalmoscope (a handheld
device that resembles a small flashlight). Doctors also look for areas of
swelling, particularly in the legs, hands, and face. Any swollen areas are
checked to see if they are red, warm, or tender.
Testing
If deep vein thrombosis is suspected, Doppler
ultrasonography of the affected leg is done. This test can show disturbances in
blood flow caused by blood clots in the leg veins.
If preeclampsia is suspected, the protein level is measured
in a urine sample. High blood pressure plus a high protein level in urine
indicates preeclampsia. If the diagnosis is unclear, the woman is asked to
collect her urine for 24 hours, and protein is measured in that volume of
urine. This measurement is more accurate. However, preeclampsia may also be
present if the protein level in urine is normal. High blood pressure with
headache, changes in vision, abdominal pain, or abnormal blood or urine test
results may also indicate preeclampsia.
If peripartum cardiomyopathy is suspected,
electrocardiography, chest x-ray, echocardiography, and blood tests to check
heart function are done.
Treatment
When swelling results from a disorder, that disorder is
treated.
The swelling that occurs normally during pregnancy can be
reduced by doing the following:
Lying on the left side, which moves the uterus off the large
vein that returns blood to the heart (inferior vena cava)
Resting frequently with the legs elevated
Wearing elastic support stockings
Wearing loose clothing that does not restrict blood flow,
particularly in the legs (for example, not wearing socks or stockings that have
tight bands around the ankles or calves)
Key Points
Some swelling in the legs and ankles is normal (physiologic)
during pregnancy and occurs during the 3rd trimester.
Doctors can identify serious causes of swelling based on
results of a physical examination, blood pressure measurement, blood and urine
tests, and sometimes ultrasonography.
If pregnancy itself is the cause, swelling can be reduced by
lying on the left side, elevating the legs periodically, wearing support
stockings, and wearing clothing that does not restrict blood flow
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