Vaginal Bleeding During Early Pregnancy
During the first 20 weeks of pregnancy, 20 to 30% of women
have vaginal bleeding. In about half of these women, the pregnancy ends in a
miscarriage. If miscarriage does not occur immediately, problems later in the
pregnancy are possible. For example, the baby's birth weight may be low, or the
baby may be born early ( preterm birth), be born dead ( stillbirth), or die
during or shortly after birth. If bleeding is profuse, blood pressure may
become dangerously low, resulting in shock. However, many women with light
bleeding in early pregnancy go on to have a healthy pregnancy and delivery.
The amount of bleeding can range from spots of blood to a
massive amount. Passing large amounts of blood is always a concern, but
spotting or mild bleeding may also indicate a serious disorder.
Causes
Vaginal bleeding during early pregnancy may result from
disorders related to the pregnancy (obstetric) or not (see table Some Causes
and Features of Vaginal Bleeding During Early Pregnancy).
The most common cause of vaginal bleeding during early pregnancy is
A miscarriage
There are different degrees of miscarriage (also called
spontaneous abortion). A miscarriage may be possible (threatened abortion) or
certain to occur (inevitable abortion). All of the contents of the uterus
(fetus and placenta) may be expelled (complete abortion) or not (incomplete
abortion). The contents of the uterus may be infected before, during, or after
the miscarriage (septic abortion). The fetus may die in the uterus and remain
there (missed abortion). Any type of miscarriage can cause vaginal bleeding
during early pregnancy.
The most dangerous cause of vaginal bleeding during early
pregnancy is
Rupture of an abnormally located pregnancy ( ectopic
pregnancy)—one that is not in its usual place in the uterus—for example, one
that is in a fallopian tube
Another possibly dangerous but less common cause is rupture
of a corpus luteum cyst. After an egg is released, the structure that released
it (the corpus luteum) may fill with fluid or blood instead of breaking down
and disappearing as it usually does.
If an ectopic pregnancy or a corpus luteum cyst ruptures,
bleeding may be profuse, leading to shock.
Risk factors
For miscarriage, risk factors include the following:
Age over 35
One or more miscarriages in previous pregnancies
Cigarette smoking
Use of drugs such as cocaine, alcohol, or consumption of a
lot of caffeine
Abnormalities in the uterus, such as fibroids, scarring, or
an abnormal shape of the uterus
Poorly controlled medical disorders such as diabetes,
thyroid disease, or lupus
For ectopic pregnancy, risk factors include
A previous ectopic pregnancy (the most important risk
factor)
Previous abdominal surgery, especially for permanent
sterilization (tubal ligation)
A previous infection with a sexually transmitted infection
or pelvic inflammatory disease
Cigarette smoking
Use of an intrauterine device (IUD)
Age over 35
A history of infertility, use of fertility drugs, or use of
assisted reproductive techniques (in vitro fertilization)
Several sex partners
Vaginal douching
Doctors first determine whether the cause of vaginal
bleeding is an ectopic pregnancy.
Warning signs
In pregnant women with vaginal bleeding during early
pregnancy, the following symptoms are cause for concern:
Fainting, light-headedness, or a racing heart—symptoms that
suggest very low blood pressure
Loss of large amounts of blood or blood that contains tissue
or large clots
Severe abdominal pain that worsens when the woman moves or
changes positions
Fever, chills, and a vaginal discharge that contains pus
mixed with the blood
When to see a doctor
Women with warning signs should see a doctor immediately.
Women without warning signs should see a doctor within 48 to
72 hours.
What the doctor does
Doctors ask about the symptoms and medical history
(including past pregnancies, miscarriages, abortions, and risk factors for
ectopic pregnancy and miscarriage). Doctors then do a physical examination.
What they find during the history and physical examination often suggests a
cause and the tests that may need to be done (see table Some Causes and
Features of Vaginal Bleeding During Early Pregnancy).
Doctors ask about the bleeding:
How severe it is (for example, how many pads are used or
soaked in an hour)
Whether clots or tissue were passed
Whether pain accompanies the bleeding
If pain is present, doctors ask when and how it started,
where it occurs, how long it lasts, whether it is sharp or dull, and whether it
is constant or comes and goes.
During the physical examination, doctors first check for
fever and signs of substantial blood loss, such as a racing heart and low blood
pressure. They then do a pelvic examination, checking to see whether the cervix
(the lower part of the uterus) has started to open (dilate) to enable the
pregnancy to pass through. If any tissue (possibly from a miscarriage) is
detected, it is removed and sent to a laboratory to be analyzed.
Doctors also gently press on the abdomen to see whether it
is tender when touched.
Testing
During the examination, doctors may use a handheld Doppler
ultrasound device, placed on the woman's abdomen, to check for a heartbeat in
the fetus.
If a home pregnancy test indicates pregnancy but pregnancy
has not been confirmed by a health care practitioner, doctors do a pregnancy
test using a urine sample.
Once pregnancy is confirmed, several tests are done:
Blood type and Rh status (positive or negative)
Usually ultrasonography
Usually blood tests to measure a hormone (human chorionic
gonadotropin, or hCG) produced by the placenta during early pregnancy
Rh status is determined because a pregnant woman with
Rh-negative blood must be treated with Rho(D) immune globulin if she has any
vaginal bleeding. Treatment is needed to prevent her from producing antibodies
that may attack the fetus's red blood cells in subsequent pregnancies (see Rh
Incompatibility).
If bleeding is substantial (more than about a cup), doctors
also do a complete blood cell count (CBC) and tests to check for abnormal
antibodies or to cross-match blood (to determine whether the woman’s blood type
is compatible with a donor’s in case blood transfusion is needed). If blood
loss is substantial or shock develops, blood tests are done to determine
whether blood can clot normally.
Typically, ultrasonography is done using an ultrasound
device inserted into the vagina. Ultrasonography can detect a pregnancy in the
uterus and can detect a heartbeat after about 6 weeks of pregnancy. If no
heartbeat is detected after this time, a miscarriage is diagnosed. If a
heartbeat is detected, miscarriage is much less likely but may still occur.
Ultrasonography can also help identify the following:
A miscarriage that is incomplete, is infected, or has been
missed
Any parts of the placenta or other pregnancy-related tissues
that remain in the uterus
A ruptured corpus luteum cyst
A hydatidiform mole or other form of gestational
trophoblastic disease
Sometimes an ectopic pregnancy, depending on where it is
located and how big it is
Measuring hCG levels helps doctors interpret ultrasonography
results and distinguish a normal pregnancy from an ectopic pregnancy. If the
likelihood of a ruptured ectopic pregnancy is low, hCG levels are measured
frequently and ultrasonography is repeated as needed. If the likelihood of a
ruptured ectopic pregnancy is moderate or high, doctors may make a small
incision just below the navel and insert a viewing tube (laparoscope) to
directly view the uterus and surrounding structures (laparoscopy) and thus
determine whether an ectopic pregnancy is present.
Treatment
If bleeding is profuse, if shock develops, or if a ruptured
ectopic pregnancy is likely, one of the first things doctors do is to place a
large catheter in a vein so that blood can be quickly given intravenously.
When bleeding results from a disorder, that disorder is
treated if possible. For example, surgery is done immediately when an ectopic
pregnancy has ruptured.
Although doctors have typically recommended bed rest when a
miscarriage seems possible, there is no evidence that bed rest helps prevent
miscarriage. Refraining from sexual intercourse is advised, although
intercourse has not been definitely connected with miscarriages.
Key Points
The most common cause of bleeding during early pregnancy is
a miscarriage.
The most serious cause of vaginal bleeding is an ectopic
pregnancy.
A pregnant woman should see a doctor immediately if she has
a racing heart, faints, or feels faint.
Blood tests to determine whether blood is Rh-negative or
Rh-positive are done because if a pregnant woman with Rh-negative blood has
vaginal bleeding, she must be given Rho(D) immune globulin to prevent her from
producing antibodies that may attack the fetus's red blood cells in subsequent
pregnant
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