Overview of Stroke
Strokes are a heterogeneous group of disorders involving sudden, focal interruption of cerebral blood flow that causes neurologic deficit. Strokes can be
- Ischemic (80%), typically resulting from thrombosis or embolism
- Hemorrhagic (20%), resulting from vascular rupture (eg, subarachnoid hemorrhage, intracerebral hemorrhage)
Transient stroke symptoms (typically lasting < 1 hour) without evidence of acute cerebral infarction (based on diffusion-weighted MRI) are termed a transient ischemic attack (TIA).
In the US, stroke is the 5th most common cause of death and the most common cause of neurologic disability in adults.
Brain Vasculature
Strokes involve the arteries of the brain , either the anterior circulation (branches of the internal carotid
artery) or the posterior circulation (branches of the vertebral and basilar
arteries).
Arteries of the brain
The anterior cerebral artery supplies the medial portions of the
frontal and parietal lobes and corpus callosum. The middle cerebral artery
supplies large portions of the frontal, parietal, and temporal lobe surfaces.
Branches of the anterior and middle cerebral arteries (lenticulostriate
arteries) supply the basal ganglia and anterior limb of the internal capsule.
The vertebral and basilar arteries supply the brain stem,
cerebellum, posterior cerebral cortex, and medial temporal lobe. The posterior
cerebral arteries bifurcate from the basilar artery to supply the medial
temporal (including the hippocampus) and occipital lobes, thalamus, and
mammillary and geniculate bodies.
Anterior circulation and posterior circulation communicate in the circle of Willis.
Arteries of the brain
Risk factors
The following are modifiable factors that contribute to increased risk of stroke:
·
Hypertension
·
Cigarette smoking
·
Dyslipidemia
·
Diabetes
·
Insulin resistance (1)
·
Abdominal obesity
·
Excess alcohol consumption
·
Lack of physical activity
·
High-risk diet (eg, high in
saturated fats, trans fats, and calories)
·
Psychosocial stress (eg,
depression)
·
Heart disorders (particularly
disorders that predispose to emboli, such as acute MI, infective endocarditis,
and atrial fibrillation)
·
Hypercoagulability (thrombotic
stroke only)
·
Intracranial aneurysms
(subarachnoid hemorrhage only)
·
Use of certain drugs (eg,
cocaine, amphetamines)
·
Vasculitis
Unmodifiable risk factors include the following:
·
Prior stroke
·
Older age
·
Family history of stroke
·
Genetic factors
Symptoms and Signs of Stroke
Initial symptoms of stroke occur suddenly. Symptoms depend on the location of infarction
Thus, symptoms can include numbness, weakness of limbs or face;
aphasia; confusion; visual disturbances in one or both eyes (eg, transient
monocular blindness); dizziness or loss of balance and coordination; and
headache. alert-info
Areas of the brain by function
Neurologic deficits are used to determine the location of stroke .
Anterior circulation stroke typically causes unilateral symptoms. Posterior
circulation stroke can cause unilateral or bilateral deficits and is more
likely to affect consciousness, especially when the basilar artery is involved.
Systemic or autonomic disturbances (eg, hypertension, fever) occasionally occur.
Other manifestations, rather than neurologic deficits, often suggest the type of stroke. For example,
·
Sudden, severe headache
suggests subarachnoid hemorrhage.
·
Impaired consciousness or coma,
often accompanied by headache, nausea, and vomiting, suggests increased
intracranial pressure, which can occur 48 to 72 hours after large ischemic
strokes and earlier in many hemorrhagic strokes; fatal brain herniation may
result.
Complications
Stroke complications can include sleep problems, confusion,
depression, incontinence, atelectasis, pneumonia, and swallowing dysfunction,
which can lead to aspiration, dehydration, or undernutrition. Immobility can lead
to thromboembolic disease, deconditioning, sarcopenia, urinary tractinfections, pressure ulcers, and contractures.
Daily functioning (including the ability to walk, see, feel,
remember, think, and speak) may be decreased.
Evaluation of Stroke
Evaluation aims to establish the following:
·
Whether stroke has occurred
·
Whether stroke is ischemic or
hemorrhagic
·
Whether emergency treatment is
required
·
What the best strategies for
preventing subsequent strokes are
·
Whether and how to pursue
rehabilitation
Stroke is suspected in patients with any of the following:
·
Sudden neurologic deficits
compatible with brain damage in an arterial territory
·
A particularly sudden, severe
headache
·
Sudden, unexplained coma
·
Sudden impairment of
consciousness
·
Glucose is measured at bedside
to rule out hypoglycemia.
If stroke is still suspected, immediate neuroimaging is required to
differentiate hemorrhagic from ischemic stroke and to detect signs of increased
intracranial pressure. CT is sensitive for intracranial blood but may be normal
or show only subtle changes during the first hours of symptoms after anterior
circulation ischemic stroke. CT also misses some small posterior circulation
strokes. MRI is sensitive for intracranial blood and may detect signs of
ischemic stroke missed by CT, but CT can usually be done more rapidly. If CT
does not confirm clinically suspected stroke, diffusion-weighted MRI can
usually detect ischemic stroke.
If consciousness is impaired and lateralizing signs are absent or equivocal, further tests to check for other causes are done.
After the stroke is identified as ischemic or hemorrhagic, tests are
done to determine the cause. Patients are also evaluated for coexisting acute
general disorders (eg, infection, dehydration, hypoxia, hyperglycemia,
hypertension). Patients are asked about depression, which commonly occurs after
stroke. A dysphagia team evaluates swallowing; sometimes a barium swallow study
is necessary.
Treatment of Stroke
·
Stabilization
·
Reperfusion for some ischemic
strokes
·
Supportive measures and
treatment of complications
·
Strategies to prevent future
strokes
Stabilization may need to precede complete evaluation. Comatose or
obtunded patients (eg, Glasgow Coma Score ≤ 8) may require airway support. If
increased intracranial pressure is suspected, intracranial pressure monitoring
and measures to reduce cerebral edema may be necessary.
Specific acute treatments vary by type of stroke. They may include
reperfusion (eg, recombinant tissue plasminogen activator, thrombolysis,
mechanical thrombectomy) for some ischemic strokes.
Strategies to Prevent and Treat Stroke Complications
After a stroke, most patients require rehabilitation (occupational
and physical therapy) to maximize functional recovery. Some need additional
therapies (eg, speech therapy, feeding restrictions). For rehabilitation, an
interdisciplinary approach is best.
Depression after stroke may require antidepressants; many patients benefit from counseling.
Modifying risk factors through lifestyle changes (eg, stopping
cigarette smoking) and drug therapy (eg, for hypertension) can help delay or
prevent subsequent strokes. Other stroke prevention strategies are chosen based
on the patient's risk factors. For ischemic stroke prevention, strategies may
include procedures (eg, carotid endarterectomy, stent placement), antiplatelet
therapy, and anticoagulation.
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